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Na(+) Permeation and Block of hERG Potassium Channels
The inactivation gating of hERG channels is important for the channel function and drug–channel interaction. Whereas hERG channels are highly selective for K(+), we have found that inactivated hERG channels allow Na(+) to permeate in the absence of K(+). This provides a new way to directly monitor a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151557/ https://ncbi.nlm.nih.gov/pubmed/16769794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609500 |
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