Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels

BACKGROUND AND PURPOSE: Transient receptor potential canonical (TRPC) channels play important roles in a broad array of physiological functions and are involved in various diseases. However, due to a lack of potent subtype-specific inhibitors the exact roles of TRPC channels in physiological and pat...

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Publicado no:Br J Pharmacol
Main Authors: Zhu, Yingmin, Lu, Yungang, Qu, Chunrong, Miller, Melissa, Tian, Jinbin, Thakur, Dhananjay P, Zhu, Jinmei, Deng, Zixin, Hu, Xianming, Wu, Meng, McManus, Owen B, Li, Min, Hong, Xuechuan, Zhu, Michael X, Luo, Huai-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507155/
https://ncbi.nlm.nih.gov/pubmed/25816897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13140
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