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Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

Transient receptor potential canonical (TRPC) channels are widely expressed in brain and involved in various aspects of brain function. Both TRPC4 and TRPC5 have been implicated in innate fear function, which represents a key response to environmental stress. However, to what extent the TRPC4/C5 cha...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yang, Li-Ping, Jiang, Fang-Jie, Wu, Gui-Sheng, Deng, Ke, Wen, Meng, Zhou, Xiaoju, Hong, Xuechuan, Zhu, Michael X., Luo, Huai-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552833/
https://ncbi.nlm.nih.gov/pubmed/26317356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136255
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