S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

Glutamatergic dysfunctions are observed in the pathophysiology of depression. The glutamatergic synapse as well as the AMPA receptor’s (AMPAR) activation may represent new potential targets for therapeutic intervention in the context of major depressive disorders. S 47445 is a novel AMPARs positive...

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Publicado en:Front Pharmacol
Autores principales: Mendez-David, Indira, Guilloux, Jean-Philippe, Papp, Mariusz, Tritschler, Laurent, Mocaer, Elisabeth, Gardier, Alain M., Bretin, Sylvie, David, Denis J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515821/
https://ncbi.nlm.nih.gov/pubmed/28769796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00462
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