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Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

Transient receptor potential canonical (TRPC) channels are widely expressed in brain and involved in various aspects of brain function. Both TRPC4 and TRPC5 have been implicated in innate fear function, which represents a key response to environmental stress. However, to what extent the TRPC4/C5 cha...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Yang, Li-Ping, Jiang, Fang-Jie, Wu, Gui-Sheng, Deng, Ke, Wen, Meng, Zhou, Xiaoju, Hong, Xuechuan, Zhu, Michael X., Luo, Huai-Rong
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552833/
https://ncbi.nlm.nih.gov/pubmed/26317356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136255
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