Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

BACKGROUND: Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels highly expressed in regions of the cortex and amygdala, ar...

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Publicado no:PLoS One
Main Authors: Just, Stefan, Chenard, Bertrand L., Ceci, Angelo, Strassmaier, Timothy, Chong, Jayhong A., Blair, Nathaniel T., Gallaschun, Randall J., del Camino, Donato, Cantin, Susan, D’Amours, Marc, Eickmeier, Christian, Fanger, Christopher M., Hecker, Carsten, Hessler, David P., Hengerer, Bastian, Kroker, Katja S., Malekiani, Sam, Mihalek, Robert, McLaughlin, Joseph, Rast, Georg, Witek, JoAnn, Sauer, Achim, Pryce, Christopher R., Moran, Magdalene M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791972/
https://ncbi.nlm.nih.gov/pubmed/29385160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191225
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