Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice

BACKGROUND: Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels highly expressed in regions of the cortex and amygdala, ar...

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Vydáno v:PLoS One
Hlavní autoři: Just, Stefan, Chenard, Bertrand L., Ceci, Angelo, Strassmaier, Timothy, Chong, Jayhong A., Blair, Nathaniel T., Gallaschun, Randall J., del Camino, Donato, Cantin, Susan, D’Amours, Marc, Eickmeier, Christian, Fanger, Christopher M., Hecker, Carsten, Hessler, David P., Hengerer, Bastian, Kroker, Katja S., Malekiani, Sam, Mihalek, Robert, McLaughlin, Joseph, Rast, Georg, Witek, JoAnn, Sauer, Achim, Pryce, Christopher R., Moran, Magdalene M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791972/
https://ncbi.nlm.nih.gov/pubmed/29385160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191225
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