Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

[Image: see text] Herein we report the discovery, synthesis, and evaluation of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides as selective KCNQ2 (K(v)7.2) and KCNQ4 (K(v)7.4) channel openers. The best compound, 1 (ML213), has an EC(50) of 230 nM (KCNQ2) and 510 nM (KCNQ4) and is selective f...

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Detalhes bibliográficos
Main Authors: Yu, Haibo, Wu, Meng, Townsend, Steven D., Zou, Beiyan, Long, Shunyou, Daniels, J. Scott, McManus, Owen B., Li, Min, Lindsley, Craig W., Hopkins, Corey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223964/
https://ncbi.nlm.nih.gov/pubmed/22125664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200065b
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