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Discovery, Synthesis, and Structure–Activity Relationship of a Series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener
[Image: see text] Herein we report the discovery, synthesis, and evaluation of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides as selective KCNQ2 (K(v)7.2) and KCNQ4 (K(v)7.4) channel openers. The best compound, 1 (ML213), has an EC(50) of 230 nM (KCNQ2) and 510 nM (KCNQ4) and is selective f...
Shranjeno v:
| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2011
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223964/ https://ncbi.nlm.nih.gov/pubmed/22125664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200065b |
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