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Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1
Previous studies have shown that activation of mouse MrgC11, a G-protein coupled receptor, by its peptide ligand BAM8-22 can inhibit chronic pain. A large scale screen has been carried out to isolate small molecule allosteric agonists of MrgX1, the human homologue of MrgC11. The goal of this study i...
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Publicado no: | ChemMedChem |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276534/ https://ncbi.nlm.nih.gov/pubmed/25209672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402277 |
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