Is Parkinson’s disease a lysosomal disorder?

Por Klein, Andrés D, Mazzulli, Joseph R
Publicado no Brain (2018)

Molecular Mechanisms of α-Synuclein and GBA1 in Parkinson’s Disease

Por Stojkovska, Iva, Krainc, Dimitri, Mazzulli, Joseph R.
Publicado no Cell Tissue Res (2017)

Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization

Por Waxman, Elisa A., Mazzulli, Joseph R., Giasson, Benoit I.
Publicado em 2009

Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence

Por Mazzulli, Joseph R., Burbulla, Lena F., Krainc, Dimitri, Ischiropoulos, Harry
Publicado no Anal Chem (2016)

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

Por Mazzulli, Joseph R., Zunke, Friederike, Isacson, Ole, Studer, Lorenz, Krainc, Dimitri
Publicado no Proc Natl Acad Sci U S A (2016)

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity

Por Usenovic, Marija, Tresse, Emilie, Mazzulli, Joseph R., Taylor, J. Paul, Krainc, Dimitri
Publicado em 2012

Distinct Region-Specific α-Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration

Por Tsika, Elpida, Moysidou, Maria, Guo, Jing, Cushman, Mimi, Gannon, Patrick, Sandaltzopoulos, Raphael, Giasson, Benoit I., Krainc, Dimitri, Ischiropoulos, Harry, Mazzulli, Joseph R.
Publicado em 2010

Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway

Por Cohen, Dena E., Cui, Libin, Supinski, Andrea, Savas, Jeffrey N., Mazzulli, Joseph R., Yates, John R., Bordone, Laura, Guarente, Leonard P., Krainc, Dimitri
Publicado em 2011

Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2

Por Zunke, Friederike, Andresen, Lisa, Wesseler, Sophia, Groth, Johann, Arnold, Philipp, Rothaug, Michelle, Mazzulli, Joseph R., Krainc, Dimitri, Blanz, Judith, Saftig, Paul, Schwake, Michael
Publicado no Proc Natl Acad Sci U S A (2016)

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

Por Zunke, Friederike, Moise, Alexandra C., Belur, Nandkishore R., Gelyana, Eilrayna, Stojkovska, Iva, Dzaferbegovic, Haris, Toker, Nicholas J., Jeon, Sohee, Fredriksen, Kristina, Mazzulli, Joseph R.
Publicado no Neuron (2017)

Gaucher’s Disease Glucocerebrosidase and <alpha>-synuclein form a bidirectional pathogenic loop in synucleinopathies

Por Mazzulli, Joseph R., Xu, You-Hai, Sun, Ying, Knight, Adam L., McLean, Pamela J., Caldwell, Guy A., Sidransky, Ellen, Grabowski, Gregory A., Krainc, Dimitri
Publicado em 2011

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

Por Jeong, Hyunkyung, Then, Florian, Melia, Thomas J., Mazzulli, Joseph R., Cui, Libin, Savas, Jeffrey N., Voisine, Cindy, Paganetti, Paolo, Tanese, Naoko, Hart, Anne C., Yamamoto, Ai, Krainc, Dimitri
Publicado em 2009

Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

Por Mazzulli, Joseph R., Zunke, Friederike, Tsunemi, Taiji, Toker, Nicholas J., Jeon, Sohee, Burbulla, Lena F., Patnaik, Samarjit, Sidransky, Ellen, Marugan, Juan J., Sue, Carolyn M., Krainc, Dimitri
Publicado no J Neurosci (2016)

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

Por Rothaug, Michelle, Zunke, Friederike, Mazzulli, Joseph R., Schweizer, Michaela, Altmeppen, Hermann, Lüllmann-Rauch, Renate, Kallemeijn, Wouter W., Gaspar, Paulo, Aerts, Johannes M., Glatzel, Markus, Saftig, Paul, Krainc, Dimitri, Schwake, Michael, Blanz, Judith
Publicado em 2014

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Por Chung, Sun Young, Kishinevsky, Sarah, Mazzulli, Joseph R., Graziotto, John, Mrejeru, Ana, Mosharov, Eugene V., Puspita, Lesly, Valiulahi, Parvin, Sulzer, David, Milner, Teresa A., Taldone, Tony, Krainc, Dimitri, Studer, Lorenz, Shim, Jae-won
Publicado no Stem Cell Reports (2016)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

Por Mor, Danielle E., Tsika, Elpida, Mazzulli, Joseph R., Gould, Neal S., Kim, Hanna, Daniels, Malcolm J., Doshi, Shachee, Gupta, Preetika, Grossman, Jennifer L., Tan, Victor X., Kalb, Robert G., Caldwell, Kim A., Caldwell, Guy A., Wolfe, John H., Ischiropoulos, Harry
Publicado no Nat Neurosci (2017)

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Por Burbulla, Lena F., Song, Pingping, Mazzulli, Joseph R., Zampese, Enrico, Wong, Yvette C., Jeon, Sohee, Santos, David P., Blanz, Judith, Obermaier, Carolin D., Strojny, Chelsee, Savas, Jeffrey N., Kiskinis, Evangelos, Zhuang, Xiaoxi, Krüger, Rejko, Surmeier, D. James, Krainc, Dimitri
Publicado no Science (2017)

THE GLYCOLYTIC ENZYME, GPI-1, IS A FUNCTIONALLY CONSERVED MODIFIER OF DOPAMINERIGIC NEURODEGENERATION IN PARKINSON’S MODELS([GC1])

Por Knight, Adam L., Yan, Xiaohui, Hamamichi, Shusei, Ajjuri, Rami R., Mazzulli, Joseph R., Zhang, Mike W., Daigle, J. Gavin, Zhang, Siyuan, Borom, Akeem R., Roberts, Lindsay R., Lee, S. Kyle, DeLeon, Susan M., Viollet-Djelassi, Coralie, Krainc, Dimitri, O’Donnell, Janis M., Caldwell, Kim A., Caldwell, Guy A.
Publicado em 2014

Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons

Por Chung, Chee Yeun, Khurana, Vikram, Auluck, Pavan K., Tardiff, Daniel F., Mazzulli, Joseph R., Soldner, Frank, Baru, Valeriya, Lou, Yali, Freyzon, Yelena, Cho, Sukhee, Mungenast, Alison E., Muffat, Julien, Mitalipova, Maisam, Pluth, Michael D, Jui, Nathan T., Schüle, Birgitt, Lippard, Stephen J., Tsai, Li-Huei, Krainc, Dimitri, Buchwald, Stephen L., Jaenisch, Rudolf, Lindquist, Susan
Publicado em 2013

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

Por Schultheis, Patrick J., Fleming, Sheila M., Clippinger, Amy K., Lewis, Jada, Tsunemi, Taiji, Giasson, Benoit, Dickson, Dennis W., Mazzulli, Joseph R., Bardgett, Mark E., Haik, Kristi L., Ekhator, Osunde, Chava, Anil Kumar, Howard, John, Gannon, Matt, Hoffman, Elizabeth, Chen, Yinhuai, Prasad, Vikram, Linn, Stephen C., Tamargo, Rafael J., Westbroek, Wendy, Sidransky, Ellen, Krainc, Dimitri, Shull, Gary E.
Publicado em 2013