Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway

Sirt1, an NAD-dependent protein deacetylase has emerged as important regulator of mammalian transcription in response to cellular metabolic status and stress(1). Here we demonstrate that Sirt1 plays a neuroprotective role in models of Huntington’s disease (HD), an inherited neurodegenerative disorde...

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Main Authors: Cohen, Dena E., Cui, Libin, Supinski, Andrea, Savas, Jeffrey N., Mazzulli, Joseph R., Yates, John R., Bordone, Laura, Guarente, Leonard P., Krainc, Dimitri
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509213/
https://ncbi.nlm.nih.gov/pubmed/22179316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2559
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