Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

Huntington’s disease (HD) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is expected to prevent cellular dysfunction and neurodegeneration in HD. We report here that such clearance can be achieved...

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Detalhes bibliográficos
Main Authors: Jeong, Hyunkyung, Then, Florian, Melia, Thomas J., Mazzulli, Joseph R., Cui, Libin, Savas, Jeffrey N., Voisine, Cindy, Paganetti, Paolo, Tanese, Naoko, Hart, Anne C., Yamamoto, Ai, Krainc, Dimitri
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940108/
https://ncbi.nlm.nih.gov/pubmed/19345187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.018
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