Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

Huntington’s disease (HD) is an incurable neurodegenerative disease caused by neuronal accumulation of the mutant protein huntingtin. Improving clearance of the mutant protein is expected to prevent cellular dysfunction and neurodegeneration in HD. We report here that such clearance can be achieved...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jeong, Hyunkyung, Then, Florian, Melia, Thomas J., Mazzulli, Joseph R., Cui, Libin, Savas, Jeffrey N., Voisine, Cindy, Paganetti, Paolo, Tanese, Naoko, Hart, Anne C., Yamamoto, Ai, Krainc, Dimitri
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2009
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940108/
https://ncbi.nlm.nih.gov/pubmed/19345187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.018
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