Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis

Huntington disease is a neurodegenerative disorder caused by a CAG repeat amplification in the gene huntingtin (HTT) that is reflected by a polyglutamine expansion in the Htt protein. Nearly 20 years of research have uncovered roles for Htt in a wide range of cellular processes, and many of these di...

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Detalhes bibliográficos
Main Authors: Culver, Brady P., Savas, Jeffrey N., Park, Sung K., Choi, Jeong H., Zheng, Shuqiu, Zeitlin, Scott O., Yates, John R., Tanese, Naoko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381125/
https://ncbi.nlm.nih.gov/pubmed/22556411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359307
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