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Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional signif...

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Detalhes bibliográficos
Main Authors: Ma, Bin, Savas, Jeffrey N., Yu, Man-Shan, Culver, Brady P., Chao, Moses V., Tanese, Naoko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216621/
https://ncbi.nlm.nih.gov/pubmed/22355657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00140
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