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scyllo-Inositol Promotes Robust Mutant Huntingtin Protein Degradation
Huntington disease is characterized by neuronal aggregates and inclusions containing polyglutamine-expanded huntingtin protein and peptide fragments (polyQ-Htt). We have used an established cell-based assay employing a PC12 cell line overexpressing truncated exon 1 of Htt with a 103-residue polyQ ex...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3916565/ https://ncbi.nlm.nih.gov/pubmed/24352657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.501635 |
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