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Inhibition of Rho Kinases Enhances the Degradation of Mutant Huntingtin
Huntington disease (HD) is a fatal hereditary neurodegenerative disease caused by an expansion of the polyglutamine (polyQ) stretch in huntingtin (htt). Whereas the pathological significance of the expanded polyQ has been clearly established and a tremendous effort to develop therapeutic tools for H...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2676047/ https://ncbi.nlm.nih.gov/pubmed/19278999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809229200 |
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