Inhibition of Rho Kinases Enhances the Degradation of Mutant Huntingtin

Huntington disease (HD) is a fatal hereditary neurodegenerative disease caused by an expansion of the polyglutamine (polyQ) stretch in huntingtin (htt). Whereas the pathological significance of the expanded polyQ has been clearly established and a tremendous effort to develop therapeutic tools for H...

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Hlavní autoři: Bauer, Peter O., Wong, Hon Kit, Oyama, Fumitaka, Goswami, Anand, Okuno, Misako, Kino, Yoshihiro, Miyazaki, Haruko, Nukina, Nobuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Protein Synthesis, Post-Translational Modification, and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676047/
https://ncbi.nlm.nih.gov/pubmed/19278999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809229200
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