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Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor
In Huntington's disease (HD), mutant Huntingtin, which contains expanded polyglutamine stretches, forms nuclear aggregates in neurons. The interactions of several transcriptional factors with mutant Huntingtin, as well as altered expression of many genes in HD models, imply the involvement of t...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2274932/ https://ncbi.nlm.nih.gov/pubmed/18288205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.23 |
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