Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

In Huntington's disease (HD), mutant Huntingtin, which contains expanded polyglutamine stretches, forms nuclear aggregates in neurons. The interactions of several transcriptional factors with mutant Huntingtin, as well as altered expression of many genes in HD models, imply the involvement of t...

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Main Authors: Yamanaka, Tomoyuki, Miyazaki, Haruko, Oyama, Fumitaka, Kurosawa, Masaru, Washizu, Chika, Doi, Hiroshi, Nukina, Nobuyuki
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2274932/
https://ncbi.nlm.nih.gov/pubmed/18288205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.23
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