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ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
BACKGROUND: Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract. Activation of the channel responsible for the inositol-induced Ca(2+) release from ensoplasmic...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3502191/ https://ncbi.nlm.nih.gov/pubmed/22929228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-43 |
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