ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

BACKGROUND: Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract. Activation of the channel responsible for the inositol-induced Ca(2+) release from ensoplasmic...

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Autores principales: Bauer, Peter O, Hudec, Roman, Goswami, Anand, Kurosawa, Masaru, Matsumoto, Gen, Mikoshiba, Katsuhiko, Nukina, Nobuyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502191/
https://ncbi.nlm.nih.gov/pubmed/22929228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-43
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