Post-aggregation Oxidation of Mutant Huntingtin Controls the Interactions between Aggregates

Por Mitomi, Yasushi, Nomura, Takao, Kurosawa, Masaru, Nukina, Nobuyuki, Furukawa, Yoshiaki
Publicado em 2012

Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity

Por Nekooki-Machida, Yoko, Kurosawa, Masaru, Nukina, Nobuyuki, Ito, Kazuki, Oda, Toshiro, Tanaka, Motomasa
Publicado em 2009

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

Por Yamanaka, Tomoyuki, Miyazaki, Haruko, Oyama, Fumitaka, Kurosawa, Masaru, Washizu, Chika, Doi, Hiroshi, Nukina, Nobuyuki
Publicado em 2008

Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction

Por Yamanaka, Tomoyuki, Tosaki, Asako, Miyazaki, Haruko, Kurosawa, Masaru, Furukawa, Yoshiaki, Yamada, Mizuki, Nukina, Nobuyuki
Publicado em 2010

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

Por Bauer, Peter O, Hudec, Roman, Goswami, Anand, Kurosawa, Masaru, Matsumoto, Gen, Mikoshiba, Katsuhiko, Nukina, Nobuyuki
Publicado em 2012

Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations

Por Kino, Yoshihiro, Washizu, Chika, Aquilanti, Elisa, Okuno, Misako, Kurosawa, Masaru, Yamada, Mizuki, Doi, Hiroshi, Nukina, Nobuyuki
Publicado em 2011

Loss of aPKCλ in Differentiated Neurons Disrupts the Polarity Complex but Does Not Induce Obvious Neuronal Loss or Disorientation in Mouse Brains

Por Yamanaka, Tomoyuki, Tosaki, Asako, Kurosawa, Masaru, Akimoto, Kazunori, Hirose, Tomonori, Ohno, Shigeo, Hattori, Nobutaka, Nukina, Nobuyuki
Publicado em 2013

Large-Scale RNA Interference Screening in Mammalian Cells Identifies Novel Regulators of Mutant Huntingtin Aggregation

Por Yamanaka, Tomoyuki, Wong, Hon Kit, Tosaki, Asako, Bauer, Peter O., Wada, Koji, Kurosawa, Masaru, Shimogori, Tomomi, Hattori, Nobutaka, Nukina, Nobuyuki
Publicado em 2014

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS

Por Yamanaka, Tomoyuki, Tosaki, Asako, Miyazaki, Haruko, Kurosawa, Masaru, Koike, Masato, Uchiyama, Yasuo, Maity, Sankar N., Misawa, Hidemi, Takahashi, Ryosuke, Shimogori, Tomomi, Hattori, Nobutaka, Nukina, Nobuyuki
Publicado no Sci Rep (2016)

FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis

Por Kino, Yoshihiro, Washizu, Chika, Kurosawa, Masaru, Yamada, Mizuki, Miyazaki, Haruko, Akagi, Takumi, Hashikawa, Tsutomu, Doi, Hiroshi, Takumi, Toru, Hicks, Geoffrey G, Hattori, Nobutaka, Shimogori, Tomomi, Nukina, Nobuyuki
Publicado no Acta Neuropathol Commun (2015)

FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice

Por Kino, Yoshihiro, Washizu, Chika, Kurosawa, Masaru, Yamada, Mizuki, Doi, Hiroshi, Takumi, Toru, Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Hicks, Geoffrey G., Hattori, Nobutaka, Shimogori, Tomomi, Nukina, Nobuyuki
Publicado no Sci Rep (2016)

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease

Por Tanaka, Motomasa, Ishizuka, Koko, Nekooki-Machida, Yoko, Endo, Ryo, Takashima, Noriko, Sasaki, Hideyuki, Komi, Yusuke, Gathercole, Amy, Huston, Elaine, Ishii, Kazuhiro, Hui, Kelvin Kai-Wan, Kurosawa, Masaru, Kim, Sun-Hong, Nukina, Nobuyuki, Takimoto, Eiki, Houslay, Miles D., Sawa, Akira
Publicado no J Clin Invest (2017)