Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations

TLS (translocated in liposarcoma), also known as FUS (fused in sarcoma), is an RNA/DNA-binding protein that plays regulatory roles in transcription, pre-mRNA splicing and mRNA transport. Mutations in TLS are responsible for familial amyotrophic lateral sclerosis (ALS) type 6. Furthermore, TLS-contai...

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Detalhes bibliográficos
Main Authors: Kino, Yoshihiro, Washizu, Chika, Aquilanti, Elisa, Okuno, Misako, Kurosawa, Masaru, Yamada, Mizuki, Doi, Hiroshi, Nukina, Nobuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074126/
https://ncbi.nlm.nih.gov/pubmed/21109527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1162
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