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Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction

In polyglutamine diseases including Huntington's disease (HD), mutant proteins containing expanded polyglutamine stretches form nuclear aggregates in neurons. Although analysis of their disease models suggested a significance of transcriptional dysregulation in these diseases, how it mediates t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yamanaka, Tomoyuki, Tosaki, Asako, Miyazaki, Haruko, Kurosawa, Masaru, Furukawa, Yoshiaki, Yamada, Mizuki, Nukina, Nobuyuki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865370/
https://ncbi.nlm.nih.gov/pubmed/20185558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq087
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