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Large-Scale RNA Interference Screening in Mammalian Cells Identifies Novel Regulators of Mutant Huntingtin Aggregation

In polyglutamine (polyQ) diseases including Huntington's disease (HD), mutant proteins containing expanded polyQ stretch form aggregates in neurons. Genetic or RNAi screenings in yeast, C. elegans or Drosophila have identified multiple genes modifying polyQ aggregation, a few of which are confi...

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書誌詳細
主要な著者: Yamanaka, Tomoyuki, Wong, Hon Kit, Tosaki, Asako, Bauer, Peter O., Wada, Koji, Kurosawa, Masaru, Shimogori, Tomomi, Hattori, Nobutaka, Nukina, Nobuyuki
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976342/
https://ncbi.nlm.nih.gov/pubmed/24705917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093891
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