Large-Scale RNA Interference Screening in Mammalian Cells Identifies Novel Regulators of Mutant Huntingtin Aggregation

In polyglutamine (polyQ) diseases including Huntington's disease (HD), mutant proteins containing expanded polyQ stretch form aggregates in neurons. Genetic or RNAi screenings in yeast, C. elegans or Drosophila have identified multiple genes modifying polyQ aggregation, a few of which are confi...

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Detaylı Bibliyografya
Asıl Yazarlar: Yamanaka, Tomoyuki, Wong, Hon Kit, Tosaki, Asako, Bauer, Peter O., Wada, Koji, Kurosawa, Masaru, Shimogori, Tomomi, Hattori, Nobutaka, Nukina, Nobuyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976342/
https://ncbi.nlm.nih.gov/pubmed/24705917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093891
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