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Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity
A hallmark of polyglutamine diseases, including Huntington disease (HD), is the formation of β-sheet-rich aggregates, called amyloid, of causative proteins with expanded polyglutamines. However, it has remained unclear whether the polyglutamine amyloid is a direct cause or simply a secondary manifes...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2689308/ https://ncbi.nlm.nih.gov/pubmed/19487684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812083106 |
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