Tadpole-like conformations of huntingtin exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length

Soluble huntingtin exon 1 (Httex1) with expanded polyglutamine (polyQ) engenders neurotoxicity in Huntington’s disease. To uncover the physical basis of this toxicity, we performed structural studies of soluble Httex1 for wild type and mutant polyQ lengths. Nuclear magnetic resonance experiments sho...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Mol Biol
Egile Nagusiak: Newcombe, Estella A., Ruff, Kiersten M., Sethi, Ashish, Ormsby, Angelique R., Ramdzan, Yasmin M., Fox, Archa, Purcell, Anthony W., Gooley, Paul R., Pappu, Rohit V., Hatters, Danny M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963539/
https://ncbi.nlm.nih.gov/pubmed/29627459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.03.031
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak