Tadpole-like conformations of huntingtin exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length

Soluble huntingtin exon 1 (Httex1) with expanded polyglutamine (polyQ) engenders neurotoxicity in Huntington’s disease. To uncover the physical basis of this toxicity, we performed structural studies of soluble Httex1 for wild type and mutant polyQ lengths. Nuclear magnetic resonance experiments sho...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Newcombe, Estella A., Ruff, Kiersten M., Sethi, Ashish, Ormsby, Angelique R., Ramdzan, Yasmin M., Fox, Archa, Purcell, Anthony W., Gooley, Paul R., Pappu, Rohit V., Hatters, Danny M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963539/
https://ncbi.nlm.nih.gov/pubmed/29627459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.03.031
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados