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A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences

The aggregation of proteins with expanded polyglutamine (polyQ) tracts is directly relevant to the formation of neuronal intranuclear inclusions in Huntington’s disease. In vitro studies have uncovered the effects of flanking sequences as modulators of the driving forces and mechanisms of polyQ aggr...

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書誌詳細
主要な著者: Ruff, Kiersten M., Khan, Siddique J., Pappu, Rohit V.
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156672/
https://ncbi.nlm.nih.gov/pubmed/25185558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.019
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