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A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences
The aggregation of proteins with expanded polyglutamine (polyQ) tracts is directly relevant to the formation of neuronal intranuclear inclusions in Huntington’s disease. In vitro studies have uncovered the effects of flanking sequences as modulators of the driving forces and mechanisms of polyQ aggr...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156672/ https://ncbi.nlm.nih.gov/pubmed/25185558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.019 |
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