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Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

Huntington disease is caused by mutational expansion of the CAG trinucleotide within exon 1 of the huntingtin (Htt) gene. Exon 1 spanning N-terminal fragments (NTFs) of the Htt protein result from aberrant splicing of transcripts of mutant Htt. NTFs typically encompass a polyglutamine tract flanked...

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Bibliografiske detaljer
Main Authors: Crick, Scott L., Ruff, Kiersten M., Garai, Kanchan, Frieden, Carl, Pappu, Rohit V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864320/
https://ncbi.nlm.nih.gov/pubmed/24282292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320626110
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