Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range of neurotoxic aggregates that are associated with Huntington's disease. Here, we show that aggregation of Htt-NTFs, irrespective of polyglutamine length, yields at least three phases (designated M, S, and...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Posey, Ammon E., Ruff, Kiersten M., Harmon, Tyler S., Crick, Scott L., Li, Aimin, Diamond, Marc I., Pappu, Rohit V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846159/
https://ncbi.nlm.nih.gov/pubmed/29358329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000357
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