Huntingtin Fragments and SOD1 Mutants Form Soluble Oligomers in the Cell

Diffusion coefficients of huntingtin (Htt) fragments and SOD1 mutants expressed in cells were measured using fluorescence correlation spectroscopy. The diffusion mobilities of both non-pathological Htt fragments (25 polyQs) and pathological Htt fragments (103 polyQs) were much slower than expected f...

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Main Authors: Park, Yang-Nim, Zhao, Xiaohong, Norton, Mark, Taylor, J. Paul, Eisenberg, Evan, Greene, Lois E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386994/
https://ncbi.nlm.nih.gov/pubmed/22768276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040329
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