Huntingtin Fragments and SOD1 Mutants Form Soluble Oligomers in the Cell

Diffusion coefficients of huntingtin (Htt) fragments and SOD1 mutants expressed in cells were measured using fluorescence correlation spectroscopy. The diffusion mobilities of both non-pathological Htt fragments (25 polyQs) and pathological Htt fragments (103 polyQs) were much slower than expected f...

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Détails bibliographiques
Auteurs principaux: Park, Yang-Nim, Zhao, Xiaohong, Norton, Mark, Taylor, J. Paul, Eisenberg, Evan, Greene, Lois E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386994/
https://ncbi.nlm.nih.gov/pubmed/22768276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040329
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