Visualization of cell-to-cell transmission of mutant huntingtin oligomers

We developed a new cell model for the visualization of toxic huntingtin oligomers in living cells. Huntingtin exon 1 (25Q or 103Q) was fused to non-fluorescent halves of the Venus protein. When huntingtin dimerizes inside the cells, Venus becomes functionally reconstituted and emits fluorescence. Ol...

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Bibliografiske detaljer
Main Authors: Herrera, Federico, Tenreiro, Sandra, Miller-Fleming, Leonor, Outeiro, Tiago Fleming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Huntington Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037516/
https://ncbi.nlm.nih.gov/pubmed/21331289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1210
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