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Visualization of cell-to-cell transmission of mutant huntingtin oligomers
We developed a new cell model for the visualization of toxic huntingtin oligomers in living cells. Huntingtin exon 1 (25Q or 103Q) was fused to non-fluorescent halves of the Venus protein. When huntingtin dimerizes inside the cells, Venus becomes functionally reconstituted and emits fluorescence. Ol...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037516/ https://ncbi.nlm.nih.gov/pubmed/21331289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1210 |
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