Visualization of cell-to-cell transmission of mutant huntingtin oligomers

We developed a new cell model for the visualization of toxic huntingtin oligomers in living cells. Huntingtin exon 1 (25Q or 103Q) was fused to non-fluorescent halves of the Venus protein. When huntingtin dimerizes inside the cells, Venus becomes functionally reconstituted and emits fluorescence. Ol...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Herrera, Federico, Tenreiro, Sandra, Miller-Fleming, Leonor, Outeiro, Tiago Fleming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Huntington Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037516/
https://ncbi.nlm.nih.gov/pubmed/21331289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1210
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller