Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity

Huntington disease (HD) is a neurodegenerative disorder caused by the expansion of a polyglutamine tract in the huntingtin (htt) protein. To uncover candidate therapeutic targets and networks involved in pathogenesis, we integrated gene expression profiling and functional genetic screening to identi...

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Detalhes bibliográficos
Main Authors: Tauber, Eran, Miller-Fleming, Leonor, Mason, Robert P., Kwan, Wanda, Clapp, Jannine, Butler, Nicola J., Outeiro, Tiago F., Muchowski, Paul J., Giorgini, Flaviano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Genomics and Proteomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012999/
https://ncbi.nlm.nih.gov/pubmed/21044956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.101527
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