Mutant huntingtin impairs immune cell migration in Huntington disease

In Huntington disease (HD), immune cells are activated before symptoms arise; however, it is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of immune cells. Here we report that primary microglia from early postnatal HD mice were profoundly impaired in their mi...

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Autores principales: Kwan, Wanda, Träger, Ulrike, Davalos, Dimitrios, Chou, Austin, Bouchard, Jill, Andre, Ralph, Miller, Aaron, Weiss, Andreas, Giorgini, Flaviano, Cheah, Christine, Möller, Thomas, Stella, Nephi, Akassoglou, Katerina, Tabrizi, Sarah J., Muchowski, Paul J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533551/
https://ncbi.nlm.nih.gov/pubmed/23160193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64484
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