Mutant huntingtin impairs immune cell migration in Huntington disease

In Huntington disease (HD), immune cells are activated before symptoms arise; however, it is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of immune cells. Here we report that primary microglia from early postnatal HD mice were profoundly impaired in their mi...

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Detalhes bibliográficos
Main Authors: Kwan, Wanda, Träger, Ulrike, Davalos, Dimitrios, Chou, Austin, Bouchard, Jill, Andre, Ralph, Miller, Aaron, Weiss, Andreas, Giorgini, Flaviano, Cheah, Christine, Möller, Thomas, Stella, Nephi, Akassoglou, Katerina, Tabrizi, Sarah J., Muchowski, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533551/
https://ncbi.nlm.nih.gov/pubmed/23160193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64484
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