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Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (HTT) protein. The expression of mutant HTT in the baker’s yeast Saccharomyces cerevisiae recapitulates many of the cellular phenotypes observed in mammalian HD models. Mutant H...

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Bibliografiska uppgifter
Huvudupphovsmän: Kantcheva, Ralitsa B., Mason, Robert, Giorgini, Flaviano
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006944/
https://ncbi.nlm.nih.gov/pubmed/24804153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.501008f3051342c9a5c0cd0f3a5bf3a4
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