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Delayed emergence of subdiffractionsized mutant huntingtin fibrils following inclusion body formation
Aberrant aggregation of improperly folded proteins is the hallmark of several human neurodegenerative disorders, including Huntington’s Disease (HD) with autosomal-dominant inheritance. In HD, expansion of the CAG-repeat-encoded polyglutamine (polyQ) stretch beyond ~40 glutamines in huntingtin (Htt)...
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| Publicado no: | Q Rev Biophys |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4785097/ https://ncbi.nlm.nih.gov/pubmed/26350150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033583515000219 |
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