Delayed emergence of subdiffractionsized mutant huntingtin fibrils following inclusion body formation

Aberrant aggregation of improperly folded proteins is the hallmark of several human neurodegenerative disorders, including Huntington’s Disease (HD) with autosomal-dominant inheritance. In HD, expansion of the CAG-repeat-encoded polyglutamine (polyQ) stretch beyond ~40 glutamines in huntingtin (Htt)...

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Bibliographic Details
Published in:Q Rev Biophys
Main Authors: Sahl, Steffen J., Lau, Lana, Vonk, Willianne I. M., Weiss, Lucien E., Frydman, Judith, Moerner, W. E.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785097/
https://ncbi.nlm.nih.gov/pubmed/26350150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0033583515000219
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