Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin

The N-terminal fragments of mutant huntingtin (mHTT) misfold and assemble into oligomers, which ultimately bundle into insoluble fibrils. Conformations unique to various assemblies of mHTT remain unknown. Knowledge on the half-life of various multimeric structures of mHTT is also scarce. Using a pan...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Ko, Jan, Isas, J Mario, Sabbaugh, Adam, Yoo, Jung Hyun, Pandey, Nitin K, Chongtham, Anjalika, Ladinsky, Mark, Wu, Wei-Li, Rohweder, Heike, Weiss, Andreas, Macdonald, Douglas, Munoz-Sanjuan, Ignacio, Langen, Ralf, Patterson, Paul H, Khoshnan, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005051/
https://ncbi.nlm.nih.gov/pubmed/29912367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy141
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