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Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils
The fact that the heritable neurodegenerative disorder Huntington’s Disease (HD) is autosomal dominant means that there is one wild type and one mutant allele in most HD patients. The CAG repeat expansion in the exon 1 of the protein huntingtin (HTT(ex1)) that causes the disease, leads to the format...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575822/ https://ncbi.nlm.nih.gov/pubmed/28621522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00138 |
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