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Formation and Structure of Wild Type Huntingtin Exon-1 Fibrils

The fact that the heritable neurodegenerative disorder Huntington’s Disease (HD) is autosomal dominant means that there is one wild type and one mutant allele in most HD patients. The CAG repeat expansion in the exon 1 of the protein huntingtin (HTT(ex1)) that causes the disease, leads to the format...

詳細記述

保存先:
書誌詳細
出版年:Biochemistry
主要な著者: Isas, J. Mario, Langen, Andreas, Isas, Myles C., Pandey, Nitin K., Siemer, Ansgar B.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575822/
https://ncbi.nlm.nih.gov/pubmed/28621522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00138
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