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Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils

Huntington’s disease is a heritable neurodegenerative disease that is caused by a CAG expansion in the first exon of the huntingtin gene. This expansion results in an elongated polyglutamine domain that increases the propensity of huntingtin exon-1 to form cross-β fibrils. Although the polyglutamine...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Falk, Alexander S., Bravo-Arredondo, José M., Varkey, Jobin, Pacheco, Sayuri, Langen, Ralf, Siemer, Ansgar B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7732765/
https://ncbi.nlm.nih.gov/pubmed/33096080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.10.010
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