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Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils
Huntington’s disease is a heritable neurodegenerative disease that is caused by a CAG expansion in the first exon of the huntingtin gene. This expansion results in an elongated polyglutamine domain that increases the propensity of huntingtin exon-1 to form cross-β fibrils. Although the polyglutamine...
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| Publicado en: | Biophys J |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Biophysical Society
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7732765/ https://ncbi.nlm.nih.gov/pubmed/33096080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.10.010 |
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