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Structural Features and Domain Organization of Huntingtin Fibrils
Misfolding and aggregation of huntingtin is one of the hallmarks of Huntington disease, but the overall structure of these aggregates and the mechanisms by which huntingtin misfolds remain poorly understood. Here we used site-directed spin labeling and electron paramagnetic resonance (EPR) spectrosc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442508/ https://ncbi.nlm.nih.gov/pubmed/22801429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353839 |
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