Fibril Structure of Human Islet Amyloid Polypeptide

Misfolding and amyloid fibril formation by human islet amyloid polypeptide (hIAPP) are thought to be important in the pathogenesis of type 2 diabetes, but the structures of the misfolded forms remain poorly understood. Here we developed an approach that combines site-directed spin labeling with cont...

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Main Authors: Bedrood, Sahar, Li, Yiyu, Isas, J. Mario, Hegde, Balachandra G., Baxa, Ulrich, Haworth, Ian S., Langen, Ralf
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285303/
https://ncbi.nlm.nih.gov/pubmed/22187437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.327817
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