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Idealized models of protofilaments of human islet amyloid polypeptide

Fibrils formed by assembly of human islet amyloid polypeptide (hIAPP) are found in most patients with type II diabetes. Structurally, these fibrils are composed of multiple protofilaments and are characterized by extended beta sheets, variable helical twists, and different morphologies. We have prev...

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Bibliografiske detaljer
Main Authors: Li, Yiyu, Hatmal, Ma'mon M., Langen, Ralf, Haworth, Ian S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522432/
https://ncbi.nlm.nih.gov/pubmed/23116372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300300e
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