The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract

Expansion of the polyglutamine (polyQ) tract in exon 1 of the huntingtin protein (Httex1) leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains poorly understood how polyQ expansions alter protein structure and cause toxicity. Using CD, EPR, and NMR spectroscop...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Bravo-Arredondo, Jose M., Kegulian, Natalie C., Schmidt, Thomas, Pandey, Nitin K., Situ, Alan J., Ulmer, Tobias S., Langen, Ralf
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314148/
https://ncbi.nlm.nih.gov/pubmed/30315108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004808
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items