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The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract
Expansion of the polyglutamine (polyQ) tract in exon 1 of the huntingtin protein (Httex1) leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains poorly understood how polyQ expansions alter protein structure and cause toxicity. Using CD, EPR, and NMR spectroscop...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314148/ https://ncbi.nlm.nih.gov/pubmed/30315108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004808 |
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