The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract

Expansion of the polyglutamine (polyQ) tract in exon 1 of the huntingtin protein (Httex1) leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains poorly understood how polyQ expansions alter protein structure and cause toxicity. Using CD, EPR, and NMR spectroscop...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Bravo-Arredondo, Jose M., Kegulian, Natalie C., Schmidt, Thomas, Pandey, Nitin K., Situ, Alan J., Ulmer, Tobias S., Langen, Ralf
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314148/
https://ncbi.nlm.nih.gov/pubmed/30315108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004808
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki