The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract

Expansion of the polyglutamine (polyQ) tract in exon 1 of the huntingtin protein (Httex1) leads to Huntington's disease resulting in fatal neurodegeneration. However, it remains poorly understood how polyQ expansions alter protein structure and cause toxicity. Using CD, EPR, and NMR spectroscop...

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Vydáno v:J Biol Chem
Hlavní autoři: Bravo-Arredondo, Jose M., Kegulian, Natalie C., Schmidt, Thomas, Pandey, Nitin K., Situ, Alan J., Ulmer, Tobias S., Langen, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314148/
https://ncbi.nlm.nih.gov/pubmed/30315108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004808
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