Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Many neurodegenerative diseases, such as Huntington’s disease, are hallmarked by the formation of intracellular inclusion bodies (IBs) that are decorated with ubiquitin, proteasomes and chaperones. The apparent enrichment of ubiquitin and components involved in protein quality control at IBs suggest...

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Vydáno v:Sci Rep
Hlavní autoři: Juenemann, Katrin, Jansen, Anne H. P., van Riel, Luigi, Merkx, Remco, Mulder, Monique P. C., An, Heeseon, Statsyuk, Alexander, Kirstein, Janine, Ovaa, Huib, Reits, Eric A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780509/
https://ncbi.nlm.nih.gov/pubmed/29362455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19538-0
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