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Aggregation-Prone Proteins Modulate Huntingtin Inclusion Body Formation in Yeast
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (HTT) protein. The expression of mutant HTT in the baker’s yeast Saccharomyces cerevisiae recapitulates many of the cellular phenotypes observed in mammalian HD models. Mutant H...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4006944/ https://ncbi.nlm.nih.gov/pubmed/24804153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.501008f3051342c9a5c0cd0f3a5bf3a4 |
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