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Huntingtin Fragments and SOD1 Mutants Form Soluble Oligomers in the Cell

Diffusion coefficients of huntingtin (Htt) fragments and SOD1 mutants expressed in cells were measured using fluorescence correlation spectroscopy. The diffusion mobilities of both non-pathological Htt fragments (25 polyQs) and pathological Htt fragments (103 polyQs) were much slower than expected f...

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Autors principals: Park, Yang-Nim, Zhao, Xiaohong, Norton, Mark, Taylor, J. Paul, Eisenberg, Evan, Greene, Lois E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386994/
https://ncbi.nlm.nih.gov/pubmed/22768276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040329
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