A Coarse-Grained Model for Polyglutamine Aggregation Modulated by Amphipathic Flanking Sequences

The aggregation of proteins with expanded polyglutamine (polyQ) tracts is directly relevant to the formation of neuronal intranuclear inclusions in Huntington’s disease. In vitro studies have uncovered the effects of flanking sequences as modulators of the driving forces and mechanisms of polyQ aggr...

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Bibliographic Details
Main Authors: Ruff, Kiersten M., Khan, Siddique J., Pappu, Rohit V.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2014
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156672/
https://ncbi.nlm.nih.gov/pubmed/25185558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.019
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